| Gene Information | |
|---|---|
| Gene Name | NEK7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 302 |
| Protein Names | Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151414 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8TDX7 |
| Gene Card | NEK7 |
| Uniprot ID | Q8TDX7 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.080364007) |
| Ortholog in Animals | Alpaca_ NEK7 ( ortholog_one2one ) Dog_ NEK7 ( ortholog_one2one ) GuineaPig_ NEK7 ( ortholog_one2one ) Macaque_ NEK7 ( ortholog_one2one ) Mouse_ Nek7 ( ortholog_one2one ) Pig_ NEK7 ( ortholog_one2one ) Rat_ Nek7 ( ortholog_one2one ) |
| Ohnologs | NEK6 |
| Paralogs | NEK5, NEK11, NEK2, NEK9, NEK3, NEK6, NEK10, NEK8 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.18(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2WQM (X-ray 2.10A ) 2WQN (X-ray 2.30A ) 5DE2 (X-ray 2.78A ) 6NPY (EM 3.80A ) 6S73 (X-ray 3.50A ) 6S75 (X-ray 3.30A ) 6S76 (X-ray 3.38A ) |
| DBSNP | rs55833332 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q9ES74}. Cytoplasm {ECO:0000269|PubMed:17586473}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19414596}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473}. Note=Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9ES74, ECO:0000269|PubMed:17586473}. |
| Mouse PG classification | NA |
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