| Gene Information | |
|---|---|
| Gene Name | NEK6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000119408 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9HC98 |
| Gene Card | NEK6 |
| Uniprot ID | Q9HC98 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.254817948) |
| Ortholog in Animals | Alpaca_ NEK6 ( ortholog_one2one ) Dog_ NEK6 ( ortholog_one2one ) GuineaPig_ NEK6 ( ortholog_one2one ) Macaque_ NEK6 ( ortholog_one2one ) Mouse_ Nek6 ( ortholog_one2one ) Pig_ NEK6 ( ortholog_one2one ) Rat_ Nek6 ( ortholog_one2one ) |
| Ohnologs | NEK7 |
| Paralogs | NEK5, NEK11, NEK2, NEK7, NEK9, NEK3, NEK10, NEK8 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. {ECO:0000269|PubMed:12054534}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis. |
| Mouse PG classification | NA |
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