| Gene Information | |
|---|---|
| Gene Name | NEK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 506 |
| Protein Names | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) |
| Target Name | serine/threonine-protein kinase nek3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136098 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P51956 |
| Gene Card | NEK3 |
| Uniprot ID | P51956 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | no (-0.183567714) |
| Ortholog in Animals | Alpaca_ NEK3 ( ortholog_one2one ) GuineaPig_ NEK3 ( ortholog_one2one ) Macaque_ NEK3 ( ortholog_one2one ) Mouse_ Nek3 ( ortholog_one2one ) Pig_ NEK3 ( ortholog_one2one ) Rat_ Nek3 ( ortholog_one2one ) Rabbit_ NEK3 ( ortholog_one2one ) |
| Ohnologs | NEK4 |
| Paralogs | NEK5, NEK11, NEK2, NEK7, NEK9, NEK6, NEK10, NEK8 |
| Tissue | NA |
| Tissue Specificity | Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain. {ECO:0000269|PubMed:12063396, ECO:0000269|PubMed:17297458}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17482764 rs55946204 rs56190615 rs56021040 rs34077016 rs55969405 rs34076988 rs34488913 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}. |
| Mouse PG classification | NA |
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