| Gene Information | |
|---|---|
| Gene Name | GRBIR |
| Organism | Homo sapiens (Human) |
| Gene Length | 594 |
| Protein Names | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13322 |
| Gene Card | GRB10 |
| Uniprot ID | Q13322 |
| Pfam | PF08947; PF00169; PF00788; PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. {ECO:0000269|PubMed:11527390}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.021238(Mouse);NULL(Rat);0.023529(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NRV (X-ray 1.65A ) 3HK0 (X-ray 2.60A ) |
| DBSNP | rs35647889 rs80244589 rs11768472 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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