Gene Information
Gene NameNEK1
OrganismHomo sapiens (Human)
Gene Length1258
Protein NamesSerine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
Target Nameserine/threonine-protein kinase nek1
Target TypeNA
Gene Age>4290 ( ENSG00000137601 )
Evolutionary StageEukaryota
AlphaFoldDBQ96PY6
Gene CardNEK1
Uniprot IDQ96PY6
PfamPF00069
In ASDno
Allosteric Predictionno (-0.396371632)
Ortholog in AnimalsAlpaca_ NEK1 ( ortholog_one2one )
Dog_ NEK1 ( ortholog_one2one )
GuineaPig_ NEK1 ( ortholog_one2one )
Macaque_ NEK1 ( ortholog_one2one )
Mouse_ Nek1 ( ortholog_one2one )
Pig_ NEK1 ( ortholog_one2one )
Rat_ Nek1 ( ortholog_one2one )
Rabbit_ NEK1 ( ortholog_one2one )
OhnologsNA
ParalogsMAP2K2, MAP2K1, MAP3K2, MAP3K4, MAP2K4, MAP3K3, MAP2K7, MAP2K5
TissueNA
Tissue SpecificityHigh fetal expression in the brain and kidney. {ECO:0000269|PubMed:21211617}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4APC  (X-ray  2.10A  )  4B9D  (X-ray  1.90A  ) 
DBSNP rs34214559  rs35093214  rs431905508  rs200161705  rs35763578  rs34540355  rs33933790  rs34324114  rs34099167  rs6828134  rs35503975 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15604234, ECO:0000305|PubMed:21211617}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P51954}. Cytoplasm {ECO:0000269|PubMed:18843199}. Note=Associated with the pericentriolar material (PubMed:21211617). Localizes to centrosome during interphase and mitosis (By similarity). Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:15604234, ECO:0000269|PubMed:21211617}.
Mouse PG classificationNA
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