| Gene Information | |
|---|---|
| Gene Name | NEIL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109674 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TAT5 |
| Gene Card | NEIL3 |
| Uniprot ID | Q8TAT5 |
| Pfam | PF06831; PF06839; PF00641 |
| In ASD | no |
| Allosteric Prediction | no (-0.670232669) |
| Ortholog in Animals | Alpaca_ NEIL3 ( ortholog_one2one ) Dog_ NEIL3 ( ortholog_one2one ) GuineaPig_ NEIL3 ( ortholog_one2one ) Macaque_ NEIL3 ( ortholog_one2one ) Mouse_ Neil3 ( ortholog_one2one ) Pig_ NEIL3 ( ortholog_one2one ) Rat_ Neil3 ( ortholog_one2one ) Rabbit_ NEIL3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEIL2, NEIL1 |
| Tissue | NA |
| Tissue Specificity | Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:22365498}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7JL5 (X-ray 2.60A ) |
| DBSNP | rs34007209 rs34112288 rs7689099 rs17064658 rs34193982 rs17064676 rs13112358 rs13112390 rs1876268 rs36005630 rs35418725 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12433996}. Chromosome {ECO:0000250|UniProtKB:A0A1L8HU22}. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. {ECO:0000250|UniProtKB:A0A1L8HU22}. |
| Mouse PG classification | NA |
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