| Gene Information | |
|---|---|
| Gene Name | S100A12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 92 |
| Protein Names | Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin] |
| Target Name | calgranulin d |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000163221 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P80511 |
| Gene Card | S100A12 |
| Uniprot ID | P80511 |
| Pfam | PF01023 |
| In ASD | no |
| Allosteric Prediction | no (-0.269855155) |
| Ortholog in Animals | Alpaca_ S100A12 ( ortholog_one2one ) Dog_ S100A8 ( ortholog_one2one ) Macaque_ S100A12 ( ortholog_one2one ) Pig_ S100A12 ( ortholog_one2one ) Rabbit_ S100A12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | S100A3, S100A10, S100A4, SNTN, S100A8, S100A13, S100A11, S100A5, S100B, S100A14, S100A16, S100Z, S100A1, S100P, S100G, S100A2, S100A7, S100A7A, CRNN, S100A9, S100A6 |
| Tissue | bone.marrow, lung, spleen, whole.blood |
| Tissue Specificity | Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E8A (X-ray 1.95A ) 1GQM (X-ray 2.70A ) 1ODB (X-ray 2.19A ) 2M9G (NMR - ) 2WC8 (X-ray 1.88A ) 2WCB (X-ray 1.73A ) 2WCE (X-ray 1.77A ) 2WCF (X-ray 2.78A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway. |
| Mouse PG classification | NA |
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