| Gene Information | |
|---|---|
| Gene Name | NEFL |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000277586 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07196 |
| Gene Card | NEFL |
| Uniprot ID | P07196 |
| Pfam | PF00038; PF04732 |
| In ASD | no |
| Allosteric Prediction | yes (0.668240428) |
| Ortholog in Animals | Alpaca_ NEFL ( ortholog_one2one ) Dog_ NEFL ( ortholog_one2one ) GuineaPig_ NEFL ( ortholog_one2one ) Macaque_ NEFL ( ortholog_one2one ) Mouse_ Nefl ( ortholog_one2one ) Pig_ NEFL ( ortholog_one2one ) Rat_ Nefl ( ortholog_one2one ) Rabbit_ NEFL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, KRT15, KRT18, KRT10 |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.069635(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs57848467 rs61491953 rs61491953 rs61491953 rs28928910 rs58332872 rs58982919 rs62636522 rs587777880 rs62636502 rs59443585 rs587777881 rs62636503 rs587777882 rs57153321 rs3832558 |
| Subcellular location [CC] | Cell projection, axon {ECO:0000250|UniProtKB:P08551}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08551}. |
| Mouse PG classification | NA |
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