Gene Information
Gene NameNECTIN4
OrganismHomo sapiens (Human)
Gene Length510
Protein NamesNectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
Target Namenectin-4
Target TypeNA
Gene Age680 ( ENSG00000143217 )
Evolutionary StageEumetazoa
AlphaFoldDBQ96NY8
Gene CardNECTIN4
Uniprot IDQ96NY8
PfamPF08205; PF07686
In ASDno
Allosteric Predictionno (-0.821324895)
Ortholog in AnimalsAlpaca_ NECTIN4 ( ortholog_one2one )
Dog_ NECTIN4 ( ortholog_one2one )
GuineaPig_ NECTIN4 ( ortholog_one2one )
Macaque_ NECTIN4 ( ortholog_one2one )
Mouse_ Nectin4 ( ortholog_one2one )
Pig_ NECTIN4 ( ortholog_one2one )
Rat_ Nectin4 ( ortholog_one2one )
Rabbit_ NECTIN4 ( ortholog_one2one )
OhnologsPVR, NECTIN1, NECTIN2, NECTIN3
ParalogsTIGIT, NCR3, CD200, NECTIN1, NECTIN2, CADM3, CADM2, CRTAM, NECTIN3, CADM4, SMAGP, CADM1, CD226, PVR
Tissueesophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina
Tissue SpecificityPredominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. {ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:17474988}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4FRW  (X-ray  3.50A  )  4GJT  (X-ray  3.10A  )  4JJH  (X-ray  2.25A  ) 
DBSNP rs3737786  rs267606992 
Subcellular location [CC]Cell membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).;
[Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).
Mouse PG classificationNA
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