| Gene Information | |
|---|---|
| Gene Name | SESN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000130766 ) 3 ( ENSG00000285069 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P58004 |
| Gene Card | SESN2 |
| Uniprot ID | P58004 |
| Pfam | PF04636 |
| In ASD | no |
| Allosteric Prediction | no (-0.161620668) |
| Ortholog in Animals | Alpaca_ SESN2 ( ortholog_one2one ) Dog_ SESN2 ( ortholog_one2one ) GuineaPig_ SESN2 ( ortholog_one2one ) Macaque_ SESN2 ( ortholog_one2one ) Mouse_ Sesn2 ( ortholog_one2one ) Pig_ SESN2 ( ortholog_one2one ) Rat_ Sesn2 ( ortholog_one2one ) Rabbit_ SESN2 ( ortholog_one2one ) |
| Ohnologs | SESN1, SESN3 |
| Paralogs | SESN1, SESN3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12607115}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5CUF (X-ray 3.50A ) 5DJ4 (X-ray 2.70A ) 5T0N (X-ray 3.00A ) 6N0M (X-ray 3.30A ) |
| DBSNP | rs2274848 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15105503}. |
| Mouse PG classification | NA |
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