| Gene Information | |
|---|---|
| Gene Name | TIL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 784 |
| Protein Names | Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O60603 |
| Gene Card | TLR2 |
| Uniprot ID | O60603 |
| Pfam | PF13855; PF01463; PF01582 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FYW (X-ray 3.00A ) 1FYX (X-ray 2.80A ) 1O77 (X-ray 3.20A ) 2Z7X (X-ray 2.10A ) 2Z80 (X-ray 1.80A ) 6NIG (X-ray 2.35A ) |
| DBSNP | rs137853176 rs5743699 rs61735277 rs5743703 rs5743704 rs137853177 rs121917864 rs5743706 rs5743708 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. {ECO:0000269|PubMed:16880211}. |
| Mouse PG classification | NA |
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