| Gene Information | |
|---|---|
| Gene Name | NGDN |
| Organism | Homo sapiens (Human) |
| Gene Length | 315 |
| Protein Names | Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129460 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NEJ9 |
| Gene Card | NGDN |
| Uniprot ID | Q8NEJ9 |
| Pfam | PF04000 |
| In ASD | no |
| Allosteric Prediction | no (-1.269306931) |
| Ortholog in Animals | Alpaca_ NGDN ( ortholog_one2one ) Dog_ NGDN ( ortholog_one2one ) GuineaPig_ NGDN ( ortholog_one2one ) Macaque_ NGDN ( ortholog_one2one ) Mouse_ Ngdn ( ortholog_one2one ) Rat_ Ngdn ( ortholog_one2one ) Rabbit_ NGDN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UTP3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.454281(Rat);0.113416(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MQ8 (EM 3.60A ) |
| DBSNP | rs10149626 rs17093050 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:18547334}. Chromosome, centromere {ECO:0000269|PubMed:18547334}. Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}. |
| Mouse PG classification | NA |
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