| Gene Information | |
|---|---|
| Gene Name | EPHA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 986 |
| Protein Names | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) |
| Target Name | ephrin type-a receptor 4 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000116106 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P54764 |
| Gene Card | EPHA4 |
| Uniprot ID | P54764 |
| Pfam | PF14575; PF01404; PF00041; PF07714; PF07647 |
| In ASD | no |
| Allosteric Prediction | yes (0.263722734) |
| Ortholog in Animals | Alpaca_ EPHA4 ( ortholog_one2one ) Dog_ EPHA4 ( ortholog_one2one ) GuineaPig_ EPHA4 ( ortholog_one2one ) Macaque_ EPHA4 ( ortholog_one2one ) Mouse_ Epha4 ( ortholog_one2one ) Pig_ EPHA4 ( ortholog_one2one ) Rat_ Epha4 ( ortholog_one2one ) Rabbit_ EPHA4 ( ortholog_one2one ) |
| Ohnologs | EPHA3, EPHA6, EPHB6, EPHA7, EPHA5, EPHA1, EPHB1, EPHB3, EPHB4, EPHA8, EPHB2, EPHA2, EPHA10 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LW8 (NMR - ) 2WO1 (X-ray 1.85A ) 2WO2 (X-ray 2.45A ) 2WO3 (X-ray 2.35A ) 3CKH (X-ray 2.80A ) 3GXU (X-ray 2.50A ) 4BK4 (X-ray 3.65A ) 4BK5 (X-ray 4.00A ) 4BKA (X-ray 5.30A ) 4BKF (X-ray 4.65A ) 4M4P (X-ray 2.08A ) 4M4R (X-ray 3.13A ) 4W4Z (X-ray 2.41A ) 4W50 (X-ray 2.42A ) 5JR2 (X-ray 1.75A ) 7OFV (X-ray 1.43A ) |
| DBSNP | rs35084379 rs756952113 rs868224085 rs35341687 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q03137}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000250}. |
| Mouse PG classification | NA |
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