| Gene Information | |
|---|---|
| Gene Name | SMPDL3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Acid sphingomyelinase-like phosphodiesterase 3a (ASM-like phosphodiesterase 3a) (EC 3.1.4.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000172594 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92484 |
| Gene Card | SMPDL3A |
| Uniprot ID | Q92484 |
| Pfam | PF19272; PF00149 |
| In ASD | no |
| Allosteric Prediction | no (-0.90233358) |
| Ortholog in Animals | Alpaca_ SMPDL3A ( ortholog_one2one ) Dog_ PKIB ( ortholog_one2one ) GuineaPig_ SMPDL3A ( ortholog_one2one ) Macaque_ SMPDL3A ( ortholog_one2one ) Mouse_ Smpdl3a ( ortholog_one2one ) Pig_ SMPDL3A ( ortholog_one2one ) Rat_ Smpdl3a ( ortholog_one2one ) Rabbit_ SMPDL3A ( ortholog_one2one ) |
| Ohnologs | SMPDL3B |
| Paralogs | SMPDL3B, SMPD1 |
| Tissue | zone.of.skin |
| Tissue Specificity | Detected in blood serum. Detected in macrophages (at protein level). {ECO:0000269|PubMed:25288789}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5EBB (X-ray 2.60A ) 5EBE (X-ray 3.00A ) |
| DBSNP | rs12523814 rs28385609 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:25288789}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |