| Gene Information | |
|---|---|
| Gene Name | NDP52 |
| Organism | Homo sapiens (Human) |
| Gene Length | 446 |
| Protein Names | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13137 |
| Gene Card | CALCOCO2 |
| Uniprot ID | Q13137 |
| Pfam | PF17751 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. {ECO:0000269|PubMed:7540613}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.008(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MXP (NMR - ) 3VVV (X-ray 1.35A ) 3VVW (X-ray 2.50A ) 4GXL (X-ray 2.02A ) 4HAN (X-ray 2.55A ) 4XKL (X-ray 2.10A ) 5AAQ (NMR - ) 5Z7A (X-ray 2.38A ) 5Z7L (X-ray 2.02A ) 7EAA (X-ray 2.60A ) |
| DBSNP | rs550510 rs2303016 rs2303015 rs17849804 rs10278 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:9230084}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25771791}; Peripheral membrane protein {ECO:0000305}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:7540613, ECO:0000269|PubMed:9230084}. |
| Mouse PG classification | NA |
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