| Gene Information | |
|---|---|
| Gene Name | NDOR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 597 |
| Protein Names | NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000188566 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UHB4 |
| Gene Card | NDOR1 |
| Uniprot ID | Q9UHB4 |
| Pfam | PF00667; PF00258; PF00175 |
| In ASD | no |
| Allosteric Prediction | no (-0.558964248) |
| Ortholog in Animals | Alpaca_ NDOR1 ( ortholog_one2one ) Dog_ NDOR1 ( ortholog_one2one ) GuineaPig_ NDOR1 ( ortholog_one2one ) Macaque_ NDOR1 ( ortholog_one2one ) Mouse_ Ndor1 ( ortholog_one2one ) Pig_ NDOR1 ( ortholog_one2one ) Rat_ Ndor1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POR, MTRR, NOS1, NOS2, NOS3 |
| Tissue | NA |
| Tissue Specificity | Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361. {ECO:0000269|PubMed:12871939}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4H2D (X-ray 1.80A ) |
| DBSNP | rs62587579 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871939}. Note=Concentrated in perinuclear structure. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:12871939}. |
| Mouse PG classification | NA |
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