| Gene Information | |
|---|---|
| Gene Name | HMOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 288 |
| Protein Names | Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] |
| Target Name | heme oxygenase 1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100292 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P09601 |
| Gene Card | HMOX1 |
| Uniprot ID | P09601 |
| Pfam | PF01126 |
| In ASD | no |
| Allosteric Prediction | yes (0.780033173) |
| Ortholog in Animals | Alpaca_ HMOX1 ( ortholog_one2one ) Dog_ HMOX1 ( ortholog_one2one ) GuineaPig_ HMOX1 ( ortholog_one2one ) Macaque_ HMOX1 ( ortholog_one2one ) Mouse_ Hmox1 ( ortholog_one2one ) Pig_ HMOX1 ( ortholog_one2one ) Rat_ Hmox1 ( ortholog_one2one ) Rabbit_ HMOX1 ( ortholog_one2one ) |
| Ohnologs | HMOX2 |
| Paralogs | HMOX2 |
| Tissue | NA |
| Tissue Specificity | Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). {ECO:0000269|PubMed:20855888}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1N3U (X-ray 2.58A ) 1N45 (X-ray 1.50A ) 1NI6 (X-ray 2.10A ) 1OYK (X-ray 2.59A ) 1OYL (X-ray 1.59A ) 1OZE (X-ray 2.19A ) 1OZL (X-ray 1.58A ) 1OZR (X-ray 1.74A ) 1OZW (X-ray 1.55A ) 1S13 (X-ray 2.29A ) 1S8C (X-ray 2.19A ) 1T5P (X-ray 2.11A ) 1TWN (X-ray 2.20A ) 1TWR (X-ray 2.10A ) 1XJZ (X-ray 1.88A ) 1XK0 (X-ray 2.18A ) 1XK1 (X-ray 2.08A ) 1XK2 (X-ray 2.20A ) 1XK3 (X-ray 2.08A ) 3CZY (X-ray 1.54A ) 3HOK (X-ray 2.19A ) 3K4F (X-ray 2.17A ) 3TGM (X-ray 2.85A ) 4WD4 (X-ray 2.95A ) 5BTQ (X-ray 2.08A ) 6EHA (X-ray 2.00A ) |
| DBSNP | rs2071747 rs9282702 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:22419571}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:22419571}. |
| Mouse PG classification | HPG |
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