| Gene Information | |
|---|---|
| Gene Name | NDFIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 221 |
| Protein Names | NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000131507 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BT67 |
| Gene Card | NDFIP1 |
| Uniprot ID | Q9BT67 |
| Pfam | PF10176 |
| In ASD | no |
| Allosteric Prediction | no (-0.491813402) |
| Ortholog in Animals | Alpaca_ NDFIP1 ( ortholog_one2one ) Dog_ NDFIP1 ( ortholog_one2one ) GuineaPig_ NDFIP1 ( ortholog_one2one ) Macaque_ NDFIP1 ( ortholog_one2one ) Mouse_ Ndfip1 ( ortholog_one2one ) Pig_ NDFIP1 ( ortholog_one2one ) Rat_ Ndfip1 ( ortholog_one2one ) Rabbit_ NDFIP1 ( ortholog_one2one ) |
| Ohnologs | NDFIP2 |
| Paralogs | NDFIP2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endosome membrane {ECO:0000269|PubMed:20534535}; Multi-pass membrane protein {ECO:0000269|PubMed:20534535}. Golgi apparatus membrane {ECO:0000269|PubMed:26363003}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8R0W6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5U2S1}. Secreted {ECO:0000269|PubMed:18819914}. Note=Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914). |
| Mouse PG classification | NA |
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