| Gene Information | |
|---|---|
| Gene Name | NDC80 |
| Organism | Homo sapiens (Human) |
| Gene Length | 642 |
| Protein Names | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000080986 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14777 |
| Gene Card | NDC80 |
| Uniprot ID | O14777 |
| Pfam | PF18077; PF03801 |
| In ASD | no |
| Allosteric Prediction | no (-0.258099711) |
| Ortholog in Animals | Alpaca_ NDC80 ( ortholog_one2one ) Dog_ NDC80 ( ortholog_one2one ) GuineaPig_ NDC80 ( ortholog_one2one ) Macaque_ NDC80 ( ortholog_one2one ) Mouse_ Ndc80 ( ortholog_one2one ) Pig_ NDC80 ( ortholog_one2one ) Rat_ Ndc80 ( ortholog_one2one ) Rabbit_ NDC80 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain, spleen, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.017453(Chimpanzee);0.068586(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IGP (X-ray 1.80A ) 2VE7 (X-ray 2.88A ) 3IZ0 (EM - ) |
| DBSNP | rs16943490 rs12456560 rs9051 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9315664}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14699129). Localizes specifically to the outer plate of the kinetochore (PubMed:14699129). {ECO:0000269|PubMed:14699129}. |
| Mouse PG classification | NA |
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