| Gene Information | |
|---|---|
| Gene Name | NCL |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | Nucleolin (Protein C23) |
| Target Name | nucleolin |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000115053 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P19338 |
| Gene Card | NCL |
| Uniprot ID | P19338 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | yes (0.429067183) |
| Ortholog in Animals | Alpaca_ NCL ( ortholog_one2one ) Dog_ NCL ( ortholog_one2one ) GuineaPig_ NCL ( ortholog_one2one ) Macaque_ NCL ( ortholog_one2one ) Mouse_ Ncl ( ortholog_one2one ) Pig_ NCL ( ortholog_one2one ) Rat_ Ncl ( ortholog_one2one ) Rabbit_ NCL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBM46, RBM19, MSI2, HNRNPA1L2, HNRNPA1L3, HNRNPA1, A1CF, RBM39, RBM23, TIAL1, DAZAP1, RBMX, RBMXL1, HNRNPA0, HNRNPAB, CIRBP, RBM3, HNRNPA3, RBMY1D, RBMY1B, RBMY1A1, RBMY1J, RBMY1F, RBMY1E, MSI1, RBM47, TRNAU1AP, HNRNPA2B1, RBMXL2, RBMXL3, RBM4, RBM4B, HNRNPD, DND1, HNRNPDL, TIA1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FC8 (NMR - ) 2FC9 (NMR - ) 2KRR (NMR - ) |
| DBSNP | rs11542691 rs11542687 rs11542689 |
| Subcellular location [CC] | Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Mouse PG classification | NA |
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