| Gene Information | |
|---|---|
| Gene Name | NCK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha) |
| Target Name | nck adaptor protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000158092 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P16333 |
| Gene Card | NCK1 |
| Uniprot ID | P16333 |
| Pfam | PF00017; PF00018; PF14604 |
| In ASD | no |
| Allosteric Prediction | yes (0.554336235) |
| Ortholog in Animals | Alpaca_ NCK1 ( ortholog_one2one ) Dog_ NCK1 ( ortholog_one2one ) GuineaPig_ NCK1 ( ortholog_one2one ) Macaque_ NCK1 ( ortholog_one2one ) Mouse_ Nck1 ( ortholog_one2one ) Pig_ NCK1 ( ortholog_one2one ) Rat_ Nck1 ( ortholog_one2one ) Rabbit_ NCK1 ( ortholog_one2one ) |
| Ohnologs | NCK2 |
| Paralogs | SLA, DAPP1, SH2D5, GRAP, GRAPL, GRB2, GRAP2, NCK2, SLA2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001668(Rat);0.032787(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CI8 (X-ray 1.80A ) 2CI9 (X-ray 1.50A ) 2CUB (NMR - ) 2JS0 (NMR - ) 2JS2 (NMR - ) 2JW4 (NMR - ) 5QU1 (X-ray 1.08A ) 5QU2 (X-ray 1.04A ) 5QU3 (X-ray 1.02A ) 5QU4 (X-ray 1.05A ) 5QU5 (X-ray 1.11A ) 5QU6 (X-ray 1.82A ) 5QU7 (X-ray 1.27A ) 5QU8 (X-ray 0.93A ) 5QUA (X-ray 1.51A ) |
| DBSNP | rs13320485 |
| Subcellular location [CC] | Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments. |
| Mouse PG classification | NA |
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