| Gene Information | |
|---|---|
| Gene Name | NCF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) |
| Target Name | nadph oxidase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000158517 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | P14598 |
| Gene Card | NCF1 |
| Uniprot ID | P14598 |
| Pfam | PF16621; PF08944; PF00787; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.594961008) |
| Ortholog in Animals | Alpaca_ NCF1 ( ortholog_one2many ) Dog_ NCF1 ( ortholog_one2one ) GuineaPig_ NCF1 ( ortholog_one2one ) Macaque_ NCF1 ( ortholog_one2one ) Mouse_ Ncf1 ( ortholog_one2one ) Pig_ NCF1 ( ortholog_one2one ) Rat_ Ncf1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NOXO1, SH3PXD2B, SH3PXD2A |
| Tissue | bone.marrow, lymph.node, spleen, whole.blood |
| Tissue Specificity | Detected in peripheral blood monocytes and neutrophils (at protein level). {ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GD5 (NMR - ) 1K4U (NMR - ) 1KQ6 (X-ray 1.18A ) 1NG2 (X-ray 1.70A ) 1O7K (X-ray 2.00A ) 1OV3 (X-ray 1.80A ) 1UEC (X-ray 1.82A ) 1W70 (X-ray 1.46A ) 1WLP (NMR - ) 7YXW (X-ray 2.50A ) |
| DBSNP | rs119103270 rs13447 rs10614 rs782555266 rs1489201208 rs13739 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:2550933}. Membrane {ECO:0000269|PubMed:12356722}; Peripheral membrane protein {ECO:0000269|PubMed:12356722}; Cytoplasmic side {ECO:0000269|PubMed:12356722}. |
| Mouse PG classification | NA |
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