| Gene Information | |
|---|---|
| Gene Name | NBR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 966 |
| Protein Names | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000188554 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14596 |
| Gene Card | NBR1 |
| Uniprot ID | Q14596 |
| Pfam | PF16158; PF00564; PF00569 |
| In ASD | no |
| Allosteric Prediction | yes (0.062753676) |
| Ortholog in Animals | Alpaca_ NBR1 ( ortholog_one2one ) Dog_ TMEM106A ( ortholog_one2one ) GuineaPig_ NBR1 ( ortholog_one2one ) Macaque_ NBR1 ( ortholog_one2one ) Mouse_ Nbr1 ( ortholog_one2one ) Pig_ NBR1 ( ortholog_one2one ) Rat_ Nbr1 ( ortholog_one2one ) Rabbit_ NBR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WJ6 (NMR - ) 2BKF (X-ray 1.56A ) 2CP8 (NMR - ) 2G4S (X-ray 2.15A ) 2L8J (NMR - ) 2MGW (NMR - ) 2MJ5 (NMR - ) 4OLE (X-ray 2.52A ) |
| DBSNP | rs8482 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:35914352}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24879152}. Lysosome {ECO:0000269|PubMed:19250911}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:19250911}. |
| Mouse PG classification | NA |
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