| Gene Information | |
|---|---|
| Gene Name | NBAS |
| Organism | Homo sapiens (Human) |
| Gene Length | 2371 |
| Protein Names | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000151779 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | A2RRP1 |
| Gene Card | NBAS |
| Uniprot ID | A2RRP1 |
| Pfam | PF15492; PF08314 |
| In ASD | no |
| Allosteric Prediction | no (-0.540693152) |
| Ortholog in Animals | Alpaca_ NBAS ( ortholog_one2one ) Dog_ NBAS ( ortholog_one2one ) Macaque_ NBAS ( ortholog_one2one ) Mouse_ Nbas ( ortholog_one2one ) Pig_ NBAS ( ortholog_one2one ) Rat_ Nbas ( ortholog_one2one ) Rabbit_ NBAS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with highest levels in heart and skeletal muscle, and lowest levels in liver, small intestine and thymus. Well expressed in retinal ganglion cells, epidermal skin cells, and leukocytes. Up-regulated together with N-myc in some neuroblastoma cell lines. {ECO:0000269|PubMed:10882752, ECO:0000269|PubMed:12706883, ECO:0000269|PubMed:20577004, ECO:0000269|PubMed:9926938}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.058298(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs77081203 rs368085185 rs1131692171 rs748880753 rs13029846 rs759960319 rs770446752 rs4668909 rs781408707 rs1085307944 rs368196005 rs781766556 rs74727069 rs140841721 rs780108348 rs16862653 rs74411619 rs796052121 rs35770368 rs779982692 rs369698072 rs6710817 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20577004}. Endoplasmic reticulum {ECO:0000269|PubMed:19369418}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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