| Gene Information | |
|---|---|
| Gene Name | NATH |
| Organism | Homo sapiens (Human) |
| Gene Length | 866 |
| Protein Names | N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BXJ9 |
| Gene Card | NAA15 |
| Uniprot ID | Q9BXJ9 |
| Pfam | PF12569; PF13181 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12087473, ECO:0000269|PubMed:12140756}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.093510(Rat);0.065333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6C95 (X-ray 3.15A ) 6C9M (X-ray 2.80A ) 6PPL (EM 3.02A ) 6PW9 (EM 4.03A ) |
| DBSNP | rs889543097 rs1436993876 rs202204424 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes. |
| Mouse PG classification | NA |
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