| Gene Information | |
|---|---|
| Gene Name | MORC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1032 |
| Protein Names | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000133422 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6X9 |
| Gene Card | MORC2 |
| Uniprot ID | Q9Y6X9 |
| Pfam | PF17942; PF07496 |
| In ASD | no |
| Allosteric Prediction | no (-1.058718038) |
| Ortholog in Animals | Alpaca_ MORC2 ( ortholog_one2one ) Dog_ MORC2 ( ortholog_one2one ) GuineaPig_ MORC2 ( ortholog_one2one ) Macaque_ MORC2 ( ortholog_one2one ) Mouse_ Morc2a ( ortholog_one2many ) Mouse_ Morc2b ( ortholog_one2many ) Pig_ MORC2 ( ortholog_one2one ) Rat_ Morc2 ( ortholog_one2many ) Rat_ Morc2b ( ortholog_one2many ) Rabbit_ MORC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MORC1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in smooth muscle, pancreas and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5OF9 (X-ray 1.81A ) 5OFA (X-ray 2.57A ) 5OFB (X-ray 2.02A ) |
| DBSNP | rs1602510214 rs1602510200 rs864309504 rs1602499659 rs749060708 rs1064795559 rs186458188 rs76273991 rs774960940 rs886037934 rs1355363942 rs864309503 rs1064796495 rs1482880426 rs1602485958 rs1555938796 rs1555938741 rs548292999 rs774444542 rs1236354994 rs759328437 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:28581500}. Cytoplasm, cytosol {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}. Chromosome {ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:28581500}. Nucleus matrix {ECO:0000269|PubMed:23260667}. Note=Mainly located in the nucleus (PubMed:20225202). Upon phosphorylation at Ser-739, recruited to damaged chromatin (PubMed:23260667). {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |