| Gene Information | |
|---|---|
| Gene Name | NARC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 692 |
| Protein Names | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NBP7 |
| Gene Card | PCSK9 |
| Uniprot ID | Q8NBP7 |
| Pfam | PF05922; PF18459; PF18464; PF18463; PF00082 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2P4E (X-ray 1.98A ) 2PMW (X-ray 2.30A ) 2QTW (X-ray 1.90A ) 2W2M (X-ray 2.40A ) 2W2N (X-ray 2.30A ) 2W2O (X-ray 2.62A ) 2W2P (X-ray 2.62A ) 2W2Q (X-ray 2.33A ) 2XTJ (X-ray 2.70A ) 3BPS (X-ray 2.41A ) 3GCW (X-ray 2.70A ) 3GCX (X-ray 2.70A ) 3H42 (X-ray 2.30A ) 3M0C (X-ray 7.01A ) 3P5B (X-ray 3.30A ) 3P5C (X-ray 4.20A ) 3SQO (X-ray 2.70A ) 4K8R (X-ray 3.22A ) 4NE9 (X-ray 2.60A ) 4NMX (X-ray 1.85A ) 4OV6 (X-ray 2.69A ) 5OCA (X-ray 2.30A ) 5VL7 (X-ray 3.50A ) 5VLA (X-ray 2.40A ) 5VLH (X-ray 2.86A ) 5VLK (X-ray 2.20A ) 5VLL (X-ray 2.37A ) 5VLP (X-ray 2.90A ) 6E4Y (X-ray 2.24A ) 6E4Z (X-ray 2.20A ) 6MV5 (X-ray 2.10A ) 6OLZ (EM 3.90A ) 6OM0 (EM 3.10A ) 6OM7 (EM 3.70A ) 6U26 (X-ray 1.53A ) 6U2F (X-ray 2.94A ) 6U2N (X-ray 2.15A ) 6U2P (X-ray 2.04A ) 6U36 (X-ray 2.70A ) 6U38 (X-ray 2.73A ) 6U3I (X-ray 2.90A ) 6U3X (X-ray 2.64A ) 7ANQ (X-ray 2.20A ) |
| DBSNP | rs11591147 rs11583680 rs145886902 rs756060557 rs151193009 rs775988212 rs28942111 rs1553135971 rs143117125 rs533273863 rs794728683 rs28942112 rs970575319 rs778617372 rs148195424 rs72646508 rs370507566 rs137852912 rs137852912 rs146471967 rs368257906 rs143275858 rs28362261 rs28362263 rs141502002 rs562556 rs141995194 rs374603772 rs1356131564 rs777300852 rs28362270 rs149311926 rs755750316 rs28362277 rs762298323 rs505151 |
| Subcellular location [CC] | Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation. |
| Mouse PG classification | NA |
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