| Gene Information | |
|---|---|
| Gene Name | FCHSD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137478 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94868 |
| Gene Card | FCHSD2 |
| Uniprot ID | O94868 |
| Pfam | PF00611; PF00018; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-1.09068809) |
| Ortholog in Animals | Alpaca_ FCHSD2 ( ortholog_one2one ) Dog_ FCHSD2 ( ortholog_one2one ) GuineaPig_ FCHSD2 ( ortholog_one2one ) Macaque_ FCHSD2 ( ortholog_one2one ) Mouse_ Fchsd2 ( ortholog_one2one ) Pig_ FCHSD2 ( ortholog_one2one ) Rat_ Fchsd2 ( ortholog_one2one ) Rabbit_ FCHSD2 ( ortholog_one2one ) |
| Ohnologs | FCHSD1 |
| Paralogs | FCHSD1 |
| Tissue | NA |
| Tissue Specificity | Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. {ECO:0000269|PubMed:14627983}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DL5 (NMR - ) 2DL7 (NMR - ) 6GBU (X-ray 3.44A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction {ECO:0000269|PubMed:14627983}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. Cell membrane {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}; Peripheral membrane protein {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}; Cytoplasmic side {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380). Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| Mouse PG classification | NA |
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