| Gene Information | |
|---|---|
| Gene Name | ARHGEF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 986 |
| Protein Names | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000116584 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q92974 |
| Gene Card | ARHGEF2 |
| Uniprot ID | Q92974 |
| Pfam | PF17838; PF00621 |
| In ASD | no |
| Allosteric Prediction | yes (0.379737613) |
| Ortholog in Animals | Alpaca_ ARHGEF2 ( ortholog_one2one ) Dog_ ARHGEF2 ( ortholog_one2one ) GuineaPig_ ARHGEF2 ( ortholog_one2one ) Macaque_ ARHGEF2 ( ortholog_one2one ) Mouse_ Arhgef2 ( ortholog_one2one ) Pig_ ARHGEF2 ( ortholog_one2one ) Rat_ Arhgef2 ( ortholog_one2one ) Rabbit_ ARHGEF2 ( ortholog_one2one ) |
| Ohnologs | ARHGEF18 |
| Paralogs | ARHGEF28, ARHGEF12, ARHGEF18, NET1, ARHGEF11, PLEKHG6, ARHGEF3, ARHGEF1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5EFX (X-ray 2.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11912491, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:9857026}. Cytoplasm {ECO:0000269|PubMed:15827085, ECO:0000269|PubMed:21887730}. Cell junction, tight junction {ECO:0000269|PubMed:19043560}. Golgi apparatus {ECO:0000269|PubMed:15827085}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17488622}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19043560}. Cytoplasmic vesicle {ECO:0000269|PubMed:21887730}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730). {ECO:0000269|PubMed:15827085, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730}. |
| Mouse PG classification | NA |
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