| Gene Information | |
|---|---|
| Gene Name | NAMPT |
| Organism | Homo sapiens (Human) |
| Gene Length | 491 |
| Protein Names | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) |
| Target Name | nicotinamide phosphoribosyltransferase |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000105835 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P43490 |
| Gene Card | NAMPT |
| Uniprot ID | P43490 |
| Pfam | PF18127; PF04095 |
| In ASD | yes |
| Allosteric Prediction | yes (0.982126751) |
| Ortholog in Animals | Alpaca_ NAMPT ( ortholog_one2one ) Dog_ NAMPT ( ortholog_one2one ) GuineaPig_ NAMPT ( ortholog_one2one ) Macaque_ NAMPT ( ortholog_one2one ) Mouse_ Nampt ( ortholog_one2one ) Pig_ NAMPT ( ortholog_one2one ) Rat_ Nampt ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NAPRT |
| Tissue | tricuspid.valve |
| Tissue Specificity | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2E5B (X-ray 2.00A ) 2E5C (X-ray 2.20A ) 2E5D (X-ray 2.00A ) 2GVG (X-ray 2.20A ) 2GVJ (X-ray 2.10A ) 3DGR (X-ray 2.10A ) 3DHD (X-ray 2.00A ) 3DHF (X-ray 1.80A ) 3DKJ (X-ray 2.00A ) 3DKL (X-ray 1.89A ) 4JNM (X-ray 2.20A ) 4JR5 (X-ray 1.91A ) 4KFN (X-ray 1.60A ) 4KFO (X-ray 1.60A ) 4KFP (X-ray 1.84A ) 4L4L (X-ray 2.12A ) 4L4M (X-ray 2.44A ) 4LTS (X-ray 1.69A ) 4LV9 (X-ray 1.81A ) 4LVA (X-ray 1.55A ) 4LVB (X-ray 1.84A ) 4LVD (X-ray 1.75A ) 4LVF (X-ray 1.50A ) 4LVG (X-ray 1.70A ) 4LWW (X-ray 1.64A ) 4M6P (X-ray 1.75A ) 4M6Q (X-ray 2.41A ) 4N9B (X-ray 2.86A ) 4N9C (X-ray 1.75A ) 4N9D (X-ray 1.70A ) 4N9E (X-ray 1.72A ) 4O0Z (X-ray 2.05A ) 4O10 (X-ray 1.55A ) 4O12 (X-ray 2.50A ) 4O13 (X-ray 1.75A ) 4O14 (X-ray 1.87A ) 4O15 (X-ray 1.80A ) 4O16 (X-ray 1.78A ) 4O17 (X-ray 1.82A ) 4O18 (X-ray 1.92A ) 4O19 (X-ray 1.75A ) 4O1A (X-ray 1.87A ) 4O1B (X-ray 1.65A ) 4O1C (X-ray 2.09A ) 4O1D (X-ray 1.70A ) 4O28 (X-ray 2.00A ) 4WQ6 (X-ray 1.72A ) 5KIT (X-ray 1.60A ) 5LX3 (X-ray 2.10A ) 5LX5 (X-ray 1.88A ) 5NSD (X-ray 2.05A ) 5U2M (X-ray 1.89A ) 5U2N (X-ray 1.73A ) 5UPE (X-ray 1.93A ) 5UPF (X-ray 1.69A ) 5WI0 (X-ray 2.05A ) 5WI1 (X-ray 1.99A ) 6ATB (X-ray 2.53A ) 6AZJ (X-ray 2.53A ) 6B75 (X-ray 2.53A ) 6B76 (X-ray 2.44A ) 6E68 (X-ray 1.50A ) 6PEB (X-ray 2.46A ) 6TA0 (X-ray 1.58A ) 6TA2 (X-ray 1.68A ) 6TAC (X-ray 1.60A ) 7ENQ (X-ray 2.20A ) 7PPE (X-ray 1.86A ) 7PPF (X-ray 2.36A ) 7PPG (X-ray 2.13A ) 7PPH (X-ray 1.74A ) 7PPI (X-ray 2.33A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}. |
| Mouse PG classification | NA |
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