| Gene Information | |
|---|---|
| Gene Name | NALP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 892 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P59044 |
| Gene Card | NLRP6 |
| Uniprot ID | P59044 |
| Pfam | PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells (PubMed:12387869). Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405). {ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:21593405}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6NCV (EM 3.70A ) 6NDJ (X-ray 2.27A ) |
| DBSNP | rs6421985 rs7482965 rs966612159 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:31932628}. Inflammasome {ECO:0000269|PubMed:12387869, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:31932628, ECO:0000269|PubMed:34678144}. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}. |
| Mouse PG classification | NA |
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