| Gene Information | |
|---|---|
| Gene Name | CPLX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 134 |
| Protein Names | Complexin-2 (Complexin II) (CPX II) (Synaphin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000145920 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6PUV4 |
| Gene Card | CPLX2 |
| Uniprot ID | Q6PUV4 |
| Pfam | PF05835 |
| In ASD | no |
| Allosteric Prediction | no (-0.895968274) |
| Ortholog in Animals | Alpaca_ CPLX2 ( ortholog_one2one ) Dog_ CPLX2 ( ortholog_one2one ) GuineaPig_ CPLX2 ( ortholog_one2one ) Mouse_ Cplx2 ( ortholog_one2one ) Pig_ CPLX2 ( ortholog_one2one ) Rat_ Cplx2 ( ortholog_one2one ) Rabbit_ CPLX2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPLX1, CPLX4, CPLX3 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:11576753, ECO:0000269|PubMed:15906159, ECO:0000269|PubMed:16162394, ECO:0000269|PubMed:9853440}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087}. Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}. |
| Mouse PG classification | NA |
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