| Gene Information | |
|---|---|
| Gene Name | NOS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 138 |
| Protein Names | Nanos homolog 2 (NOS-2) |
| Target Name | nitric-oxide synthase inducible |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000007171 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P60321 |
| Gene Card | NANOS2 |
| Uniprot ID | P60321 |
| Pfam | PF05741 |
| In ASD | no |
| Allosteric Prediction | yes (1.904724304) |
| Ortholog in Animals | Alpaca_ NOS2 ( ortholog_one2one ) Dog_ NOS2 ( ortholog_one2one ) GuineaPig_ NOS2 ( ortholog_one2one ) Macaque_ NOS2 ( ortholog_one2one ) Mouse_ Nos2 ( ortholog_one2one ) Pig_ NOS2 ( ortholog_one2one ) Rat_ Nos2 ( ortholog_one2one ) Rabbit_ NOS2 ( ortholog_one2one ) |
| Ohnologs | NOS1 |
| Paralogs | POR, MTRR, NOS1, NDOR1, NOS3 |
| Tissue | appendix, duodenum, small.intestine, rectum |
| Tissue Specificity | Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). {ECO:0000269|PubMed:19168545, ECO:0000269|PubMed:21421998}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);0.03(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs148451980 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}. |
| Mouse PG classification | HPG |
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