| Gene Information | |
|---|---|
| Gene Name | NAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 636 |
| Protein Names | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000145414 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15025 |
| Gene Card | TNIP1 |
| Uniprot ID | Q15025 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.182228354) |
| Ortholog in Animals | Alpaca_ NAF1 ( ortholog_one2one ) Dog_ NAF1 ( ortholog_one2one ) GuineaPig_ NAF1 ( ortholog_one2one ) Macaque_ NAF1 ( ortholog_one2one ) Mouse_ Naf1 ( ortholog_one2one ) Pig_ NAF1 ( ortholog_one2one ) Rat_ Naf1 ( ortholog_one2one ) Rabbit_ NAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. {ECO:0000269|PubMed:17016622}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7EAL (X-ray 2.50A ) 7EAO (X-ray 2.90A ) 7EB9 (X-ray 3.20A ) |
| DBSNP | rs2303018 rs2233289 rs2233290 rs2233292 rs2233295 rs117663772 rs185683917 rs748495842 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. |
| Mouse PG classification | NA |
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