| Gene Information | |
|---|---|
| Gene Name | NACC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 527 |
| Protein Names | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000160877 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96RE7 |
| Gene Card | NACC1 |
| Uniprot ID | Q96RE7 |
| Pfam | PF10523; PF00651 |
| In ASD | no |
| Allosteric Prediction | no (-1.337013583) |
| Ortholog in Animals | Alpaca_ NACC1 ( ortholog_one2one ) Dog_ NACC1 ( ortholog_one2one ) GuineaPig_ NACC1 ( ortholog_one2one ) Macaque_ NACC1 ( ortholog_one2one ) Mouse_ Nacc1 ( ortholog_one2one ) Pig_ NACC1 ( ortholog_one2one ) Rat_ Nacc1 ( ortholog_one2one ) |
| Ohnologs | ZBTB34, ZBTB37, ZBTB9 |
| Paralogs | FEZF1, PRDM12, ZNF280A, ZBTB33, ZBTB21, ZNF280C, NACC2, ZNF580, ZBTB26, ZNF683, ZBTB7B, GFI1, PRDM13, ZNF280B, ZBTB6, ZBTB14, GFI1B, BCL6, ZBTB49, BCL6B, ZBTB3, ZNF581, FEZF2, ZNF280D, ZBTB46, ZNF524, ZBTB12, ZBTB25 |
| Tissue | NA |
| Tissue Specificity | Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17391728}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GA1 (X-ray 2.10A ) 4U2N (X-ray 2.30A ) 7BV9 (NMR - ) |
| DBSNP | rs1060505041 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}. |
| Mouse PG classification | NA |
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