| Gene Information | |
|---|---|
| Gene Name | LTB4R |
| Organism | Homo sapiens (Human) |
| Gene Length | 352 |
| Protein Names | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) |
| Target Name | leukotriene b4 receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000213903 ) 3 ( ENSG00000285456 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15722 |
| Gene Card | LTB4R |
| Uniprot ID | Q15722 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.137386865) |
| Ortholog in Animals | Alpaca_ LTB4R ( ortholog_one2one ) Dog_ LTB4R ( ortholog_one2one ) GuineaPig_ LTB4R ( ortholog_one2one ) Macaque_ LTB4R ( ortholog_one2one ) Pig_ LTB4R ( ortholog_one2one ) Rabbit_ LTB4R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LTB4R2, SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRM1, OPRK1, PTGDR2, SSTR3, CMKLR2, SSTR1, KISS1R, UTS2R, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7K15 (X-ray 2.88A ) 7VKT (EM 2.90A ) |
| DBSNP | rs17849864 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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