| Gene Information | |
|---|---|
| Gene Name | NAALAD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000077616 ) 3 ( ENSG00000285516 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y3Q0 |
| Gene Card | NAALAD2 |
| Uniprot ID | Q9Y3Q0 |
| Pfam | PF02225; PF04389; PF04253 |
| In ASD | no |
| Allosteric Prediction | no (-0.398659516) |
| Ortholog in Animals | Alpaca_ NAALAD2 ( ortholog_one2one ) Dog_ NAALAD2 ( ortholog_one2one ) GuineaPig_ NAALAD2 ( ortholog_one2one ) Macaque_ NAALAD2 ( ortholog_one2one ) Mouse_ Naalad2 ( ortholog_one2one ) Pig_ NAALAD2 ( ortholog_one2one ) Rat_ Naalad2 ( ortholog_one2one ) Rabbit_ NAALAD2 ( ortholog_one2one ) |
| Ohnologs | NAALADL1 |
| Paralogs | FOLH1, NAALADL1, NAALADL2, TFR2, TFRC |
| Tissue | NA |
| Tissue Specificity | Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FEC (X-ray 1.49A ) 3FED (X-ray 1.29A ) 3FEE (X-ray 1.56A ) 3FF3 (X-ray 1.37A ) |
| DBSNP | rs11018879 rs10830430 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q04609}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q04609}. |
| Mouse PG classification | NA |
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