| Gene Information | |
|---|---|
| Gene Name | NAALAD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 750 |
| Protein Names | Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q04609 |
| Gene Card | FOLH1 |
| Uniprot ID | Q04609 |
| Pfam | PF02225; PF04389; PF04253 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-9 is specifically expressed in prostate cancer. {ECO:0000269|PubMed:11092759, ECO:0000269|PubMed:14716746, ECO:0000269|PubMed:16555021, ECO:0000269|PubMed:17150306}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1Z8L (X-ray 3.50A ) 2C6C (X-ray 2.00A ) 2C6G (X-ray 2.20A ) 2C6P (X-ray 2.39A ) 2CIJ (X-ray 2.40A ) 2JBJ (X-ray 2.19A ) 2JBK (X-ray 2.99A ) 2OOT (X-ray 1.64A ) 2OR4 (X-ray 1.62A ) 2PVV (X-ray 2.11A ) 2PVW (X-ray 1.71A ) 2XEF (X-ray 1.59A ) 2XEG (X-ray 1.59A ) 2XEI (X-ray 1.69A ) 2XEJ (X-ray 1.78A ) 3BHX (X-ray 1.60A ) 3BI0 (X-ray 1.67A ) 3BI1 (X-ray 1.50A ) 3BXM (X-ray 1.71A ) 3D7D (X-ray 1.69A ) 3D7F (X-ray 1.54A ) 3D7G (X-ray 1.75A ) 3D7H (X-ray 1.55A ) 3IWW (X-ray 2.30A ) 3RBU (X-ray 1.60A ) 3SJE (X-ray 1.70A ) 3SJF (X-ray 1.65A ) 3SJG (X-ray 1.65A ) 3SJX (X-ray 1.66A ) 4JYW (X-ray 1.73A ) 4JZ0 (X-ray 1.83A ) 4LQG (X-ray 1.77A ) 4MCP (X-ray 1.65A ) 4MCQ (X-ray 2.00A ) 4MCR (X-ray 1.65A ) 4MCS (X-ray 1.83A ) 4NGM (X-ray 1.84A ) 4NGN (X-ray 1.64A ) 4NGP (X-ray 1.63A ) 4NGQ (X-ray 2.08A ) 4NGR (X-ray 1.90A ) 4NGS (X-ray 1.68A ) 4NGT (X-ray 2.31A ) 4OC0 (X-ray 1.85A ) 4OC1 (X-ray 1.75A ) 4OC2 (X-ray 1.65A ) 4OC3 (X-ray 1.79A ) 4OC4 (X-ray 1.66A ) 4OC5 (X-ray 1.70A ) 4OME (X-ray 1.79A ) 4P44 (X-ray 1.75A ) 4P45 (X-ray 1.87A ) 4P4B (X-ray 1.93A ) 4P4D (X-ray 1.65A ) 4P4E (X-ray 1.67A ) 4P4F (X-ray 1.86A ) 4P4I (X-ray 1.87A ) 4P4J (X-ray 1.66A ) 4W9Y (X-ray 1.64A ) 4X3R (X-ray 1.86A ) 5D29 (X-ray 1.80A ) 5ELY (X-ray 1.81A ) 5F09 (X-ray 1.85A ) 5O5R (X-ray 1.65A ) 5O5T (X-ray 1.43A ) 5O5U (X-ray 1.53A ) 5OF0 (X-ray 1.48A ) 6ETY (X-ray 1.68A ) 6EZ9 (X-ray 1.61A ) 6F5L (X-ray 1.63A ) 6FE5 (X-ray 1.52A ) 6H7Y (X-ray 1.81A ) 6H7Z (X-ray 2.00A ) 6HKJ (X-ray 2.09A ) 6HKZ (X-ray 2.09A ) 6RBC (X-ray 1.77A ) 6RTI (X-ray 2.20A ) 6S1X (X-ray 1.76A ) 6SGP (X-ray 1.58A ) 6SKH (X-ray 1.58A ) 7BFZ (X-ray 1.73A ) |
| DBSNP | rs202676 rs61886492 rs2988342 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269|PubMed:9809977}.; [Isoform PSMA']: Cytoplasm {ECO:0000269|PubMed:9809977}. |
| Mouse PG classification | NA |
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