| Gene Information | |
|---|---|
| Gene Name | NAAA |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] |
| Target Name | n-acylethanolamine-hydrolyzing acidamidase |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000138744 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q02083 |
| Gene Card | NAAA |
| Uniprot ID | Q02083 |
| Pfam | PF02275; PF15508 |
| In ASD | no |
| Allosteric Prediction | yes (0.012530196) |
| Ortholog in Animals | Alpaca_ NAAA ( ortholog_one2one ) GuineaPig_ NAAA ( ortholog_one2one ) Macaque_ NAAA ( ortholog_one2one ) Mouse_ Naaa ( ortholog_one2one ) Pig_ NAAA ( ortholog_one2one ) Rat_ Naaa ( ortholog_one2one ) Rabbit_ NAAA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASAH1 |
| Tissue | NA |
| Tissue Specificity | Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas. {ECO:0000269|PubMed:10610717}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6DXW (X-ray 2.30A ) 6DXX (X-ray 2.70A ) |
| DBSNP | rs34751328 rs4859571 rs6823734 |
| Subcellular location [CC] | Lysosome {ECO:0000305|PubMed:10610717, ECO:0000305|PubMed:15655246, ECO:0000305|PubMed:18793752}. Membrane {ECO:0000269|PubMed:30301806}; Peripheral membrane protein {ECO:0000269|PubMed:30301806}. |
| Mouse PG classification | NA |
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