| Gene Information | |
|---|---|
| Gene Name | KASH5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 562 |
| Protein Names | Protein KASH5 (Coiled-coil domain-containing protein 155) (KASH domain-containing protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000161609 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N6L0 |
| Gene Card | KASH5 |
| Uniprot ID | Q8N6L0 |
| Pfam | PF14658; PF14662 |
| In ASD | no |
| Allosteric Prediction | no (-1.327394191) |
| Ortholog in Animals | Alpaca_ KASH5 ( ortholog_one2one ) Dog_ KASH5 ( ortholog_one2one ) GuineaPig_ KASH5 ( ortholog_one2one ) Macaque_ KASH5 ( ortholog_one2one ) Mouse_ Kash5 ( ortholog_one2one ) Pig_ KASH5 ( ortholog_one2one ) Rat_ Kash5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DUSP6, DUSP4, DUSP12, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP8, DUSP13, EPM2A, DUSP7, DUSP26, STYX, SSH2, PTPMT1, DUSP22, DUSP18, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6R2I (X-ray 1.54A ) 6WMF (X-ray 2.60A ) |
| DBSNP | rs8102582 rs10405154 |
| Subcellular location [CC] | Nucleus outer membrane {ECO:0000250|UniProtKB:Q80VJ8, ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q80VJ8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q80VJ8}. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250|UniProtKB:Q80VJ8}. |
| Mouse PG classification | NA |
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