| Gene Information | |
|---|---|
| Gene Name | INPP4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 977 |
| Protein Names | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000040933 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96PE3 |
| Gene Card | INPP4A |
| Uniprot ID | Q96PE3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.288029807) |
| Ortholog in Animals | Alpaca_ INPP4A ( ortholog_one2one ) Dog_ INPP4A ( ortholog_one2one ) GuineaPig_ INPP4A ( ortholog_one2one ) Macaque_ INPP4A ( ortholog_one2one ) Mouse_ Inpp4a ( ortholog_one2one ) Pig_ INPP4A ( ortholog_one2one ) Rat_ Inpp4a ( ortholog_one2one ) Rabbit_ INPP4A ( ortholog_one2one ) |
| Ohnologs | INPP4B |
| Paralogs | INPP4B |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. {ECO:0000269|PubMed:11485317}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2278206 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000269|PubMed:15716355}. Recycling endosome membrane {ECO:0000269|PubMed:15716355}. Cell membrane {ECO:0000269|PubMed:15716355}. Nucleus {ECO:0000269|PubMed:30071275}. Cytoplasm {ECO:0000269|PubMed:30071275}. Postsynaptic density {ECO:0000250|UniProtKB:Q9EPW0}. Note=Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275). {ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:30071275}. |
| Mouse PG classification | NA |
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