| Gene Information | |
|---|---|
| Gene Name | GMPPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000144591 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96IJ6 |
| Gene Card | GMPPA |
| Uniprot ID | Q96IJ6 |
| Pfam | PF00483 |
| In ASD | no |
| Allosteric Prediction | no (-1.220753056) |
| Ortholog in Animals | Alpaca_ GMPPA ( ortholog_one2one ) Dog_ GMPPA ( ortholog_one2one ) GuineaPig_ GMPPA ( ortholog_one2one ) Macaque_ GMPPA ( ortholog_one2one ) Mouse_ Gmppa ( ortholog_one2one ) Pig_ GMPPA ( ortholog_one2one ) Rat_ Gmppa ( ortholog_one2one ) Rabbit_ GMPPA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GMPPB, EIF2B5, EIF2B3 |
| Tissue | NA |
| Tissue Specificity | Expressed in fibroblasts (at protein level). {ECO:0000269|PubMed:24035193}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7D72 (EM 3.40A ) 7D73 (EM 3.00A ) 7D74 (EM 3.10A ) |
| DBSNP | rs34218609 rs13396066 rs397518462 rs774778439 rs397518461 rs1467274040 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24035193}. Note=Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells. |
| Mouse PG classification | NA |
| click here to return to the previous page | |