Gene Information
Gene NameATP8A1
OrganismHomo sapiens (Human)
Gene Length1164
Protein NamesPhospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1)
Target Nameprobable phospholipid-transporting atpase ia
Target TypeNA
Gene Age645 ( ENSG00000124406 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y2Q0
Gene CardATP8A1
Uniprot IDQ9Y2Q0
PfamPF16212; PF16209
In ASDno
Allosteric Predictionyes (0.050969634)
Ortholog in AnimalsAlpaca_ ATP8A1 ( ortholog_one2one )
Dog_ ATP8A1 ( ortholog_one2one )
GuineaPig_ ATP8A1 ( ortholog_one2one )
Macaque_ ATP8A1 ( ortholog_one2one )
Mouse_ Atp8a1 ( ortholog_one2one )
Pig_ ATP8A1 ( ortholog_one2one )
Rat_ Atp8a1 ( ortholog_one2one )
Rabbit_ ATP8A1 ( ortholog_one2one )
OhnologsATP8A2
ParalogsATP8B4, ATP10D, ATP11A, ATP8A2, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8B2, ATP9B, ATP8B3
TissueNA
Tissue SpecificityFound in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. Highly expressed in platelets (PubMed:30674456). {ECO:0000269|PubMed:30674456}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6K7G  (EM  3.30A  )  6K7H  (EM  3.22A  )  6K7I  (EM  3.22A  )  6K7J  (EM  3.08A  )  6K7K  (EM  3.04A  )  6K7L  (EM  2.83A  )  6K7M  (EM  2.95A  )  6K7N  (EM  2.84A  ) 
DBSNP rs3792687 
Subcellular location [CC]Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P70704};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P70704}. Cytoplasmic granule {ECO:0000269|PubMed:20947505}. Cell membrane {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Endoplasmic reticulum {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Golgi apparatus {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:20947505). In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane (PubMed:20947505). Localizes to plasma membranes of red blood cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:20947505}.
Mouse PG classificationNA
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