| Gene Information | |
|---|---|
| Gene Name | NANOS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 173 |
| Protein Names | Nanos homolog 3 (NOS-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000187556 ) 3 ( ENSG00000288505 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P60323 |
| Gene Card | NANOS3 |
| Uniprot ID | P60323 |
| Pfam | PF05741 |
| In ASD | no |
| Allosteric Prediction | no (-1.568431927) |
| Ortholog in Animals | Alpaca_ NANOS3 ( ortholog_one2one ) Dog_ NANOS3 ( ortholog_one2one ) GuineaPig_ NANOS3 ( ortholog_one2one ) Macaque_ NANOS3 ( ortholog_one2one ) Mouse_ Nanos3 ( ortholog_one2one ) Pig_ NANOS3 ( ortholog_one2one ) Rat_ Nanos3 ( ortholog_one2one ) Rabbit_ NANOS3 ( ortholog_one2one ) |
| Ohnologs | NANOS2 |
| Paralogs | NANOS2, NANOS1 |
| Tissue | NA |
| Tissue Specificity | Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269|PubMed:21421998}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P60324}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P60324}. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250|UniProtKB:P60324}. |
| Mouse PG classification | NA |
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