| Gene Information | |
|---|---|
| Gene Name | TPSAB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 275 |
| Protein Names | Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1) |
| Target Name | tryptase alpha/beta-1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000172236 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q15661 |
| Gene Card | TPSAB1 |
| Uniprot ID | Q15661 |
| Pfam | PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (0.496357947) |
| Ortholog in Animals | Alpaca_ TPSB2 ( ortholog_one2many ) Mouse_ Tpsb2 ( ortholog_many2many ) Mouse_ Tpsab1 ( ortholog_many2many ) Rat_ Tpsb2 ( ortholog_many2many ) Rat_ Tpsab1 ( ortholog_many2many ) |
| Ohnologs | TMPRSS2, TMPRSS11E, TMPRSS5 |
| Paralogs | TPSD1, TPSG1, TPSB2 |
| Tissue | lung, pancreas, sigmoid.colon |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level). {ECO:0000269|PubMed:18854315}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LTO (X-ray 2.20A ) 2F9N (X-ray 1.60A ) 2F9O (X-ray 2.10A ) 2F9P (X-ray 2.30A ) 2ZEB (X-ray 2.50A ) 2ZEC (X-ray 2.06A ) 4A6L (X-ray 2.05A ) 4MPU (X-ray 1.65A ) 4MPV (X-ray 2.31A ) 4MPW (X-ray 1.95A ) 4MPX (X-ray 2.00A ) 4MQA (X-ray 2.25A ) 5F03 (X-ray 1.94A ) 5WI6 (X-ray 2.72A ) 6O1F (X-ray 2.15A ) 6P0P (X-ray 2.55A ) 6VVU (X-ray 3.00A ) |
| DBSNP | rs371929937 rs761476435 rs562518617 rs141519544 rs146223687 rs112944038 rs1060281 rs17841227 rs17841226 rs151324823 rs201351744 rs199625169 rs202044288 rs144979264 rs200334042 rs1064780 rs149113013 rs143210825 rs202156919 rs201345428 rs1060284 rs2234905 rs2234906 rs201192435 rs145402040 rs200355084 |
| Subcellular location [CC] | Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |