| Gene Information | |
|---|---|
| Gene Name | HDGFL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 671 |
| Protein Names | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000167674 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z4V5 |
| Gene Card | HDGFL2 |
| Uniprot ID | Q7Z4V5 |
| Pfam | PF11467; PF00855 |
| In ASD | no |
| Allosteric Prediction | no (-0.653367333) |
| Ortholog in Animals | Alpaca_ HDGFL2 ( ortholog_one2one ) Dog_ HDGFL2 ( ortholog_one2one ) GuineaPig_ HDGFL2 ( ortholog_one2one ) Macaque_ HDGFL2 ( ortholog_one2one ) Mouse_ Hdgfl2 ( ortholog_one2one ) Pig_ HDGFL2 ( ortholog_one2one ) Rat_ Hdgfl2 ( ortholog_one2one ) |
| Ohnologs | PSIP1 |
| Paralogs | HDGFL3, HDGF, PSIP1, HDGFL1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples. {ECO:0000269|PubMed:25689719}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EAE (X-ray 2.24A ) 3QBY (X-ray 1.95A ) 3QJ6 (X-ray 2.30A ) 6T3I (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26721387}. Cytoplasm {ECO:0000250|UniProtKB:Q925G1}. |
| Mouse PG classification | NA |
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