| Gene Information | |
|---|---|
| Gene Name | TOP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 765 |
| Protein Names | DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) |
| Target Name | dna topoisomerase 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000198900 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P11387 |
| Gene Card | TOP1 |
| Uniprot ID | P11387 |
| Pfam | PF14370; PF01028; PF02919 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999746113) |
| Ortholog in Animals | Alpaca_ TOP1 ( ortholog_one2one ) Dog_ TOP1 ( ortholog_one2one ) GuineaPig_ TOP1 ( ortholog_one2one ) Macaque_ TOP1 ( ortholog_one2one ) Mouse_ Top1 ( ortholog_one2one ) Rat_ Top1 ( ortholog_one2one ) Rabbit_ TOP1 ( ortholog_one2one ) |
| Ohnologs | TOP1MT |
| Paralogs | TOP1MT |
| Tissue | NA |
| Tissue Specificity | Endothelial cells. {ECO:0000269|PubMed:19168442}. |
| Pharmacological Animal Models | 0.041341(Chimpanzee);0.012514(Mouse);NULL(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1A31 (X-ray 2.10A ) 1A35 (X-ray 2.50A ) 1A36 (X-ray 2.80A ) 1EJ9 (X-ray 2.60A ) 1K4S (X-ray 3.20A ) 1K4T (X-ray 2.10A ) 1LPQ (X-ray 3.14A ) 1NH3 (X-ray 3.10A ) 1R49 (X-ray 3.13A ) 1RR8 (X-ray 2.60A ) 1RRJ (X-ray 2.30A ) 1SC7 (X-ray 3.00A ) 1SEU (X-ray 3.00A ) 1T8I (X-ray 3.00A ) 1TL8 (X-ray 3.10A ) |
| DBSNP | rs6029542 rs267607131 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:12149243}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12149243}. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli. |
| Mouse PG classification | NA |
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