| Gene Information | |
|---|---|
| Gene Name | MYO1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 1108 |
| Protein Names | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) |
| Target Name | unconventional myosin-ie |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157483 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12965 |
| Gene Card | MYO1E |
| Uniprot ID | Q12965 |
| Pfam | PF00063; PF06017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.007702513) |
| Ortholog in Animals | Alpaca_ MYO1E ( ortholog_one2one ) Dog_ MYO1E ( ortholog_one2one ) GuineaPig_ MYO1E ( ortholog_one2one ) Macaque_ MYO1E ( ortholog_one2one ) Mouse_ Myo1e ( ortholog_one2one ) Pig_ MYO1E ( ortholog_one2one ) Rat_ Myo1e ( ortholog_one2one ) Rabbit_ MYO1E ( ortholog_one2one ) |
| Ohnologs | MYO1F |
| Paralogs | MYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, CGNL1, CGN, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13 |
| Tissue | NA |
| Tissue Specificity | Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes. {ECO:0000269|PubMed:21458045, ECO:0000269|PubMed:21756023}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.011256(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs387906807 rs141565214 rs1173043275 rs180951130 rs147579391 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction {ECO:0000250}. Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles. {ECO:0000250}. |
| Mouse PG classification | HPG |
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