| Gene Information | |
|---|---|
| Gene Name | CLEC5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 188 |
| Protein Names | C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000258227 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9NY25 |
| Gene Card | CLEC5A |
| Uniprot ID | Q9NY25 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.606171232) |
| Ortholog in Animals | Alpaca_ CLEC5A ( ortholog_one2one ) Alpaca_ CLEC5A ( ortholog_one2many ) Dog_ CLEC5A ( ortholog_one2one ) GuineaPig_ CLEC5A ( ortholog_one2one ) Macaque_ CLEC5A ( ortholog_one2one ) Mouse_ Clec5a ( ortholog_one2one ) Pig_ CLEC5A ( ortholog_one2one ) Rat_ Clec5a ( ortholog_one2one ) Rabbit_ CLEC5A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC2D, CLEC7A, KLRB1 |
| Tissue | bone.marrow, brain.meninx, dura.mater, hippocampus, left.atrium, lung, medulla.oblongata, zone.of.skin |
| Tissue Specificity | Highly expressed in bone marrow with lower levels in synovium, lung and bronchus (PubMed:20212065). Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins (PubMed:10449773). Expression is down-regulated when monocytes differentiate into dendritic cells (PubMed:10449773). {ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:20212065}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2YHF (X-ray 1.90A ) |
| DBSNP | rs35942193 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}. |
| Mouse PG classification | NA |
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