Gene Information
Gene NameAGK
OrganismHomo sapiens (Human)
Gene Length422
Protein NamesAcylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000006530 )
3 ( ENSG00000262327 )
Evolutionary StageEukaryota
AlphaFoldDBQ53H12
Gene CardAGK
Uniprot IDQ53H12
PfamPF19712; PF00781
In ASDno
Allosteric Predictionyes (0.402146185)
Ortholog in AnimalsAlpaca_ AGK ( ortholog_one2one )
Alpaca_ AGK ( ortholog_one2many )
Dog_ AGK ( ortholog_one2one )
GuineaPig_ AGK ( ortholog_one2one )
Macaque_ AGK ( ortholog_one2one )
Mouse_ Agk ( ortholog_one2one )
Pig_ AGK ( ortholog_one2one )
Rat_ Agk ( ortholog_one2one )
Rabbit_ AGK ( ortholog_one2one )
OhnologsNA
ParalogsCERK, SPHK1, SPHK2, CERKL
TissueNA
Tissue SpecificityHighly expressed in muscle, heart, kidney and brain. {ECO:0000269|PubMed:15939762}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7CGP  (EM  3.70A  ) 
DBSNP rs10262855 
Subcellular location [CC]Mitochondrion inner membrane {ECO:0000269|PubMed:15939762, ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726};
Peripheral membrane protein {ECO:0000269|PubMed:28712724}. Mitochondrion intermembrane space {ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}. Note=Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726). {ECO:0000269|PubMed:28712724, ECO:0000269|PubMed:28712726}.
Mouse PG classificationNA
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